An improved method for scoring protein-protein interactions using semantic similarity within the gene ontology

  title={An improved method for scoring protein-protein interactions using semantic similarity within the gene ontology},
  author={Shobhit Jain and Gary D. Bader},
  booktitle={BMC Bioinformatics},
Semantic similarity measures are useful to assess the physiological relevance of protein-protein interactions (PPIs). They quantify similarity between proteins based on their function using annotation systems like the Gene Ontology (GO). Proteins that interact in the cell are likely to be in similar locations or involved in similar biological processes compared to proteins that do not interact. Thus the more semantically similar the gene function annotations are among the interacting proteins… CONTINUE READING
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