An improved method for increasing the resolution and sensitivity of silver staining of nucleic acid bands in polyacrylamide gels.

@article{Kolodny1984AnIM,
  title={An improved method for increasing the resolution and sensitivity of silver staining of nucleic acid bands in polyacrylamide gels.},
  author={G. M. Kolodny},
  journal={Analytical biochemistry},
  year={1984},
  volume={138 1},
  pages={66-7}
}
Staining of polyacrylamide gels with methylene blue prior to silver staining increases band resolution and sensitivity. This method permits resolution of multiple bands less than 1 mm apart, and is able to detect bands containing only 100 pg of RNA. 

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