An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines

@article{Li2008AnIM,
  title={An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines},
  author={Jian Li and Lada Vuku{\vs}i{\'c} and Ning Li and Shengting Li and Guangliang Yin and Geng Tian and Shangang Jia and Kai Yuen Wang and Xiuqing Zhang and Huanming Yang and Anders Lade Nielsen and Lars Bolund},
  journal={BMC Genomics},
  year={2008},
  volume={10},
  pages={223 - 223}
}
DNA methylation is a widely studied epigenetic mechanism known to correlate with gene repression and genomic stability. Development of sensitive methods for global detection of DNA methylation events is of particular importance. We here describe a technique, called modified methylation-specific digital karyotyping (MMSDK) based on methylation-specific digital karyotyping (MSDK) with a novel sequencing approach. Briefly, after a tandem digestion of genomic DNA with a methylation-sensitive… CONTINUE READING
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