An improved implementation of effective number of codons (nc).

Abstract

The effective number of codons (N(c)) is a widely used index for characterizing codon usage bias because it does not require a set of reference genes as does codon adaptation index (CAI) and because of the freely available computational tools such as CodonW. However, N(c), as originally formulated has many problems. For example, it can have values far… (More)
DOI: 10.1093/molbev/mss201

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