An improved immunogen for anti-human chorionic gonadotropin vaccine eliciting antibodies reactive with a conformation native to the hormone without cross-reaction with human follicle stimulating hormone and human thyroid stimulating hormone.

@article{Talwar1988AnII,
  title={An improved immunogen for anti-human chorionic gonadotropin vaccine eliciting antibodies reactive with a conformation native to the hormone without cross-reaction with human follicle stimulating hormone and human thyroid stimulating hormone.},
  author={Gursaran P. Talwar and Om Pal Singh and L. V. Rao},
  journal={Journal of reproductive immunology},
  year={1988},
  volume={14 3},
  pages={
          203-12
        }
}
Bioneutralization Capacity of the Antibodies Generated in Women by the Beta Subunit of Human Chorionic Gonadotropin (βhCG) and βhCG Associated with the Alpha Subunit of Ovine Luteinizing Hormone Linked to Carriers
TLDR
In both assays, antisera of women immunized with the HSD had a bioactivity to immunoactivity ratio that was about 25% higher, on an average, than antiserA of women Immunized with β‐hCG, suggesting a better bioneutralization capacity of sera raised by the H SD in women.
Evaluation of the immunogenicity of a single chain chimeric peptide composed of hCGβ and oLHα for inhibition of the growth of hCGβ-expressing cancer cells
Human chorionic gonadotropin (hCG) is a membrane-associated protein highly expressed in several types of human cancer cells. The expression in the cancer cells indicates that hCG may be a potential
Preliminary Studies on the Indium Slide Immunoassay for Estimation of Human Chorionic Gonadotropin and Antihuman Chorionic Gonadotropin Antibody
TLDR
The indium slide assay detected anti-hCG antibodies generated against a specific determinant on hCG recognized by a neutralizing monoclonal antibody in women immunized with a contraceptive vaccine.
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References

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Isoimmunization against human chorionic gonadotropin with conjugates of processed beta-subunit of the hormone and tetanus toxoid.
The immunogenicity of the conjugate prepared from "processed" beta-subunit of human chorionic gonadotropin (choriogonadotropin, HCG) and tetanus toxoid has been studied in animals and a human
Active Immunization of Rhesus Monkeys Against the β-Subunit of Ovine Luteinizing Hormone: Evaluation of Safety and Effectiveness of an Antigonadotropin Vaccine
TLDR
The possibility of active immunization with the β-subunit or fragments of HCG as a method of fertility regulation in females has been investigated for almost two decades and several anti-HCG vaccines have reached the stage of phase I clinical trials.
Use of monoclonal antibodies to subunits of human chorionic gonadotropin to examine the orientation of the hormone in its complex with receptor.
TLDR
It is suggested that each hCG subunit participates in the hormone-receptor complex and that portions of the beta subunit project from the surface of the receptor.
Preparation and Formulation of a Human Chorionic Gonadotropin Antifertility Vaccine: Selection of a Peptide Immunogen *
TLDR
It was concluded that conjugates of β‐HCG peptide 109–145 coupled to a toxoid carrier via its N‐terminus in a ratio of 20–30 peptides per 105 daltons carrier was a suitable immunogen for further studies for the development of an anti‐fertility vaccine.
Characterization and relative orientation of epitopes for monoclonal antibodies and antisera to human chorionic gonadotropin.
TLDR
The information contained in the type of epitope map described here can be used as the rational basis for the design of two-site immunoradiometric assays for hCG and/or its subunits.
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