An improved culture system of mouse peripheral blood lymphocytes for analysis of radiation-induced chromosome aberrations.

@article{Kanda2004AnIC,
  title={An improved culture system of mouse peripheral blood lymphocytes for analysis of radiation-induced chromosome aberrations.},
  author={Reiko Kanda and Yi Shang and Satsuki Tsuji and Kiyomi Eguchi-Kasai and Isamu Hayata},
  journal={Bioscience reports},
  year={2004},
  volume={24 6},
  pages={641-50}
}
There is an incentive to develop a culture system of mouse peripheral blood lymphocytes (PBLs) to serve as models for studying genotoxic effects in humans exposed to mutagens, including ionizing radiation. However, many past approaches have been laborious, complex and only partly reproducible. In the present study, we established an improved culture system of mouse PBLs by removing blood and/or plasma, which was found to inhibit in vitro mitotic stimulation or proceeding cell cycles of… CONTINUE READING

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