An improved HPLC method with the aid of a chemometric protocol: simultaneous determination of atorvastatin and its metabolites in plasma.

@article{CrevarSaka2013AnIH,
  title={An improved HPLC method with the aid of a chemometric protocol: simultaneous determination of atorvastatin and its metabolites in plasma.},
  author={Milkica Crevar-Saka{\vc} and Zorica B Vuji{\'c} and Jasmina S Brbori{\'c} and Vesna S Kunti{\'c} and Sne{\vz}ana M Uskokovi{\'c}-Markovi{\'c}},
  journal={Molecules},
  year={2013},
  volume={18 3},
  pages={2469-82}
}
The aim of the present study was to optimize a chromatographic method for the analysis of atorvastatin (acid and lactone forms), ortho- and para-hydroxyatorvastatin by using an experimental design approach. Optimization experiments were conducted through a process of screening and optimization. The purpose of a screening design is to identify the factors… CONTINUE READING