An improved HPLC method for analysis of methamphetamine and its metabolites in plasma

@article{Li1997AnIH,
  title={An improved HPLC method for analysis of methamphetamine and its metabolites in plasma},
  author={Ning-Yuan Li and Yan Li and Edward M. Sellers},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1997},
  volume={22},
  pages={427-432}
}
An improved HPLC method for analysis of methamphetamine (MAMP) and its metabolites in plasma was established, which features: high and reliable extraction recovery without loss of the analytes during solvent evaporation; no need for sample derivatization, and simultaneous analysis of MAMP, its N-demethylation and 4-hydroxylation metabolites. The major modification on the previous extraction procedure is addition of HCl to ethyl acetate extract prior to evaporation, resulting in significant… CONTINUE READING

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