An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.

@article{Reilly2006AnIL,
  title={An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.},
  author={Karlyne M. Reilly and Karl W. Broman and Roderick Terry Bronson and Shirley Tsang and Dagan A. Loisel and Emily S Christy and Zhonghe Sun and J Alan Diehl and David J. Munroe and Robert G. Tuskan},
  journal={Cancer research},
  year={2006},
  volume={66 1},
  pages={62-8}
}
Cancer is a complex disease in which cells acquire many genetic and epigenetic alterations. We have examined how three types of alterations, mutations in tumor suppressor genes, changes in an imprinted locus, and polymorphic loci, interact to affect tumor susceptibility in a mouse model of neurofibromatosis type 1 (NF1). Mutations in tumor suppressor genes such as TP53 and in oncogenes such as KRAS have major effects on tumorigenesis due to the central roles of these genes in cell proliferation… CONTINUE READING
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