An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis.

@article{ChagasJnior2009AnIM,
  title={An imprint method for detecting leptospires in the hamster model of vaccine-mediated immunity for leptospirosis.},
  author={Adenizar Delgado Chagas-J{\'u}nior and Alan John Alexander McBride and Daniel Abensur Athanazio and Cl{\'a}udio Pereira Figueira and M A Medeiros and Mitermayer G Reis and Albert Icksang Ko and Fl{\'a}via W C McBride},
  journal={Journal of medical microbiology},
  year={2009},
  volume={58 Pt 12},
  pages={1632-7}
}
In determining the efficacy of new vaccine candidates for leptospirosis, the primary end point is death and an important secondary end point is sterilizing immunity. However, evaluation of this end point is often hampered by the time-consuming demands and complexity of methods such as culture isolation (CI). In this study, we evaluated the use of an imprint (or touch preparation) method (IM) in detecting the presence of leptospires in tissues of hamsters infected with Leptospira interrogans… CONTINUE READING
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