An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation.

@article{Kovalev2001AnIR,
  title={An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation.},
  author={Grigoriy I. Kovalev and David S. Franklin and Vernon M. Coffield and Yelin Xiong and Leon L Su},
  journal={Journal of immunology},
  year={2001},
  volume={167 6},
  pages={
          3285-92
        }
}
The inhibitors of cyclin-dependent kinase (CDK) 4 (INK4) bind CDK4/6 to prevent their association with D-cyclins and G(1) cell cycle initiation and progression. We report here that among the seven CDK inhibitors, p18(INK4c) played an important role in modulating TCR-mediated T cell proliferation. Loss of p18(INK4c) in T cells led to hyperproliferation in response to CD3 stimulation. p18(INK4c)-null mice developed lymphoproliferative disorder and T cell lymphomas. Expression of IL-2, IL-2R-alpha… CONTINUE READING
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