An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease.

@article{Das2003AnIR,
  title={An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease.},
  author={G. Sena Das and Mathew M. Augustine and Jyoti Ranjan Das and Kim Bottomly and Prabir Ray and Anuradha Ray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 9},
  pages={5324-9}
}
The normal immunoregulatory mechanisms that maintain homeostasis in the intestinal mucosa, despite continuous provocation by environmental antigens, are jeopardized in inflammatory bowel diseases. Although previous studies have suggested that intestinal intraepithelial lymphocytes prevent spontaneous intestinal inflammation, there is limited knowledge about the characteristics of regulatory cells in the intestinal intraepithelial lymphocytes population. Here we show that CD4(+)CD8 alpha alpha… CONTINUE READING