An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen.

@article{Chan2001AnIF,
  title={An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen.},
  author={Kaimin Chan and Xiao Han and Yuet Wai Kan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 8},
  pages={4611-6}
}
Nrf2, a member of the "cap 'n collar" group of transcription factors, is important for protecting cells against oxidative damage. We investigated its role in the detoxification of acetaminophen [N-acetyl-p-aminophenol (APAP)]-induced hepatotoxicity. When Nrf2 knockout (Nrf2(-/-)) and wild-type mice were given APAP by i.p. injection, the Nrf2(-/-) mice were highly susceptible to APAP treatment. With doses of APAP that were tolerated by wild-type mice, the Nrf2(-/-) mice died of liver failure… CONTINUE READING
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