An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.

@article{Trinidad2009AnIT,
  title={An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.},
  author={Eva Mar{\'i}a Molina Trinidad and Mar{\'i}a Rosa Jim{\'e}nez-Castellanos Ballesteros and Jaime Zuloaga and Agust{\'i}n G Zapata and Luis Miguel Alonso-Colmenar},
  journal={Blood},
  year={2009},
  volume={114 24},
  pages={
          5081-90
        }
}
Chronic lymphocytic leukemia (CLL) cell migration into lymphoid tissues is an important aspect of the pathobiology of this disease. Here, we investigated the role of ephrin-A4 (EFNA4) in the transendothelial migration (TEM) capacity of CLL and normal B cells through interacting with endothelial EphA2 (erythropoietin-producing hepatocellular carcinoma). CLL cells showed a remarkable impairment in the adhesion to and transmigration through human umbilical vein endothelial cell (HUVEC) monolayers… CONTINUE READING

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