An immunological biomarker to predict MTX response in early RA

@article{Ponchel2013AnIB,
  title={An immunological biomarker to predict MTX response in early RA},
  author={Frederique Ponchel and Vincent Go{\"e}b and Rekha Parmar and Yasser M. El-Sherbiny and Marjorie Boissinot and Jehan El Jawhari and Agata N. Burska and Edward M. Vital and Stephanie R Harrison and Philip G. Conaghan and Elizabeth M. A. Hensor and Paul Emery},
  journal={Annals of the Rheumatic Diseases},
  year={2013},
  volume={73},
  pages={2047 - 2053}
}
Objectives The therapeutic goal for patients with rheumatoid arthritis (RA) is clinical remission. This is best achieved by early diagnosis and appropriate therapeutic intervention. RA is associated with dysregulation of T-cell subsets (naïve, regulatory (Treg) and inflammation-related cells (IRC)) early in the disease. Our aim was to test the hypothesis that T-cell subset quantification can predict the achievement of clinical remission with early treatment in RA. Methods T-cell subsets were… 
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54 Citations
Background Citations
12
Methods Citations
3
Results Citations
3

54 Citations

A2.42 Clinical utility of measuring naÏve CD4+T-cell in early ra patient to predict remission on mtx: A replication study

This study confirms the ability of baseline naïve T-cell subset analysis in predicting early RA remission with first-line MTX therapy, suggesting clinical utility for the selection of the most appropriate therapy at disease presentation.

T cell subsets: an immunological biomarker to predict progression to clinical arthritis in ACPA-positive individuals

T cell subset dysregulation in ACPA+ individuals predates the onset of IA, predicts the risk and faster progression to IA, with added value over previously published clinical predictors of progression.

A review of Liquid biopsy as a tool to assess Epigenetic, cfDNA and miRNA variability as Methotrexate response predictors in patients with Rheumatoid Arthritis.

Response to methotrexate predicts long-term patient-related outcomes in rheumatoid arthritis

The initial response to MTX is an independent predictor of PRO in RA as assessed after an average of 18 years, and a clinical improvement of at least 20 % 1 year after the initiation of MTX was associated with a favourable outcome in all three dimensions of the ICF.

Predicting methotrexate resistance in rheumatoid arthritis patients

Progress made in the area of MTX non-response/resistance in RA patients is described, with particular focus on application of the following elements as predictive markers: proteins related to MTX transport and function, intracellular MTX concentration, immune cell frequencies, cytokines, and clinical factors.

Predicting methotrexate resistance in rheumatoid arthritis patients

Progress made in the area of MTX non-response/resistance in RA patients is described, with particular focus on application of the following elements as predictive markers: proteins related to MTX transport and function, intracellular MTX concentration, immune cell frequencies, cytokines, and clinical factors.

Diagnosis and management of early inflammatory arthritis

In early DMARD naive IA, use of bDMARD may not be superior to csDMARDs with a treat-to-target approach; in patients with MSK symptoms, anti-CCP testing identifies individuals at risk of developing IA; additional biomarkers improve prediction and are feasible for clinical use.

The advances of methotrexate resistance in rheumatoid arthritis

The recent findings regarding the critical signaling pathways of MTXR in RA are discussed, which provide research targets and directions for a drug therapy that develop preventive strategies and effective treatments ofMTXR.

RHEUMATOID ARTHRITIS: THE PROBLEMS OF REMISSION AND THERAPY RESISTANCE

Investigations are needed to study the nature of heterogeneity of pathogenetic mechanisms of RA, to improve methods for monitoring disease activity and biomarkers for the efficiency of and resistance to therapy and to develop differentiation therapy, including those related to a search for new therapeutic targets.

Quantifying circulating Th17 cells by qPCR: potential as diagnostic biomarker for rheumatoid arthritis.

The epigenetic qPCR assay showed that low levels of Th17 cells were predictive of developing RA, particularly in the ACPA-negative patients, and suggest the recruitment of Th 17 to the inflammatory disease site, consistent with high CXCR4 expression.
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