An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.


BACKGROUND A histologic hallmark of chronic rhinosinusitis (CRS) is an eosinophilic inflammation, present with and without nasal polyposis and independent of atopy. Eosinophils migrate through nasal tissue including the epithelium into the nasal airway mucus, where they form clusters and degranulate, releasing granule proteins including the toxic major… (More)
DOI: 10.1002/alr.21421