An immunohistochemical study of heat shock protein-27 in the hippocampus in a gerbil model of cerebral ischemia and ischemic tolerance.

@article{Kato1995AnIS,
  title={An immunohistochemical study of heat shock protein-27 in the hippocampus in a gerbil model of cerebral ischemia and ischemic tolerance.},
  author={Hidehito Kato and Takaaki Araki and Y. Itoyama and Kyuya Kogure and Kikuya Kato},
  journal={Neuroscience},
  year={1995},
  volume={68 1},
  pages={65-71}
}
Preconditioning of the gerbil brain with a 2-min period of sublethal ischemia protects against neuronal damage following a subsequent 3-min period of ischemia which normally damages CA1 neurons of the hippocampus (ischemic tolerance). In this study, we investigated the role of a small stress protein, heat shock protein-27, in the induction of ischemic tolerance. For this purpose, we used immunohistochemistry with an antibody against heat shock protein-27. Normal hippocampus contained very low… CONTINUE READING

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