An immunohistochemical evaluation of c-erbB-2 expression in human breast carcinoma.


The c-erbB-2 gene codes for a putative transmembrane protein, similar in structure to the epidermal growth factor (EGF) receptor. Amplification of the gene has been described in a variety of human adenocarcinomas and is particularly well documented in breast carcinoma. It has been suggested that amplification is indicative of poor prognosis and, as such, is… (More)
DOI: 10.1038/bjc.1988.238

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