An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.

@article{Yekkirala2013AnIC,
  title={An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.},
  author={Ajay Yekkirala and Alexander E. Kalyuzhny and Philip S. Portoghese},
  journal={ACS chemical biology},
  year={2013},
  volume={8 7},
  pages={1412-6}
}
Bivalent ligands that contain two pharmacophores linked by a spacer are promising tools to investigate the pharmacology of opioid receptor heteromers. Evidence for occupation of neighboring protomers by two phamacophores of a single bivalent ligand (bridging) has relied mainly on pharmacological data. In the present study, we have employed an immunocytochemical correlate to support in vivo biological studies that are consistent with bridging. We show that a bivalent mu agonist/delta antagonist… CONTINUE READING
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