An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.

@article{Wikby2005AnIR,
  title={An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.},
  author={Anders Wikby and Frederick G. Ferguson and Rosalyn J Forsey and Julie Thompson and Jan Strindhall and Sture L{\"o}fgren and Bengt-Olof Nilsson and Jan Ernerudh and Graham Pawelec and Boo Johansson},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2005},
  volume={60 5},
  pages={
          556-65
        }
}
In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86-94 years). Immune system measurements consisted of determinations of… CONTINUE READING

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