An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites.

@article{Abraham2005AnIS,
  title={An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites.},
  author={Eappen G Abraham and Sofia B. Pinto and Anil Ghosh and Dana L Vanlandingham and Aidan Budd and Stephen Higgs and Fotis C. Kafatos and Marcelo Jacobs-Lorena and Kristin Michel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 45},
  pages={
          16327-32
        }
}
We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi and Anopheles gambiae using phylogenetic, molecular, reverse genetic, and cell biological tools. The results strongly implicate SRPN6 in the innate immune response against Plasmodium. This gene belongs to a mosquito-specific gene cluster including three additional Anopheles serpins. SRPN6 expression is induced by Escherichia coli and both rodent and human malaria parasites. The gene is specifically expressed in… CONTINUE READING

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