An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss.

@article{OBrienSimpson2005AnIR,
  title={An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss.},
  author={Neil M O'Brien-Simpson and Rishi D. Pathirana and Rita A. Paolini and Yu-Yen Chen and Paul D. Veith and Vivian Tam and Nafisa Ally and Robert N. Pike and Eric C Reynolds},
  journal={Journal of immunology},
  year={2005},
  volume={175 6},
  pages={3980-9}
}
Porphyromonas gingivalis, a pathogen associated with periodontitis, bound to fibrinogen, fibronectin, hemoglobin, and collagen type V with a similar profile to that of its major virulence factor, the cell surface RgpA-Kgp proteinase-adhesin complex. Using peptide-specific, purified Abs in competitive inhibition ELISAs and epitope mapping assays, we have identified potential adhesin binding motifs (ABMs) of the RgpA-Kgp complex responsible for binding to host proteins. The RgpA-Kgp complex and… CONTINUE READING
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