An iminosugar with potent inhibition of dengue virus infection in vivo.

@article{Perry2013AnIW,
  title={An iminosugar with potent inhibition of dengue virus infection in vivo.},
  author={Stuart T. Perry and Michael D. Buck and Emily M. Plummer and Raju A Penmasta and Hitesh Batra and Eric J. Stavale and Kelly Lyn Warfield and Raymond A. Dwek and Terry D. Butters and Dominic S. Alonzi and Steven M. Lada and K. R. King and Brennan Klose and Urban Ramstedt and Sujan Shresta},
  journal={Antiviral research},
  year={2013},
  volume={98 1},
  pages={35-43}
}
The aim of the present study was to evaluate the ability of the iminosugar drug UV-4 to provide in vivo protection from lethal dengue virus (DENV) challenge. This study utilized a well-described model of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)-like lethal disease in AG129 mice lacking the type I and II interferon receptors. Herein, we… CONTINUE READING