An imidazodiazepine derivative, Ro 15-1788, behaves as a weak partial agonist in the crossed extensor reflex.

@article{Kawasaki1984AnID,
  title={An imidazodiazepine derivative, Ro 15-1788, behaves as a weak partial agonist in the crossed extensor reflex.},
  author={Koh Kawasaki and Masazumi Kodama and A. Matsushita},
  journal={European journal of pharmacology},
  year={1984},
  volume={102 1},
  pages={147-50}
}
The antagonistic and intrinsic activity of an imidazodiazepine derivative, Ro 15-1788, was manifested on the crossed extensor reflex. Ro 15-1788 antagonized the depressant effect of diazepam and shifted the dose-response curve of diazepam to the right in a parallel manner but could not reverse the depression produced by either phenobarbital or chlorpromazine. Ro 15-1788 also antagonized the enhancement produced by ethyl-beta-carboline-3-carboxylate. When administered alone, Ro 15-1788 showed a… CONTINUE READING