An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris.

@article{Pretel2009AnII,
  title={An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris.},
  author={Maider Pretel and Agust{\'i}n Espa{\~n}a and Miren Marquina and Beatriz Pelacho and Jos{\'e} Mar{\'i}a L{\'o}pez L{\'o}pez-Picazo and Mar{\'i}a Jes{\'u}s L{\'o}pez-Zabalza},
  journal={Experimental dermatology},
  year={2009},
  volume={18 9},
  pages={771-80}
}
Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by the presence of IgG autoantibodies against Dsg3. Our aim was to investigate the molecular events implicated in the development and localization of apoptosis and acantholysis in PV. We used a passive transfer mouse model together with immunohistochemical (IHC) techniques and the TUNEL assay, with quantification analysis in the basal layer of the epidermis. The activated signalling molecules analysed and apoptotic cells… CONTINUE READING