An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E–PlexinD1 signaling

@inproceedings{Tata2014AnIR,
  title={An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E–PlexinD1 signaling},
  author={Aleksandra Tata and David Christopher Stoppel and Shangyu Hong and Ayal Ben-Zvi and Tiao Xie and Chenghua Gu},
  booktitle={The Journal of cell biology},
  year={2014}
}
Extracellular signals have to be precisely interpreted intracellularly and translated into diverse cellular behaviors often mediated by cytoskeletal changes. Semaphorins are one of the largest families of guidance cues and play a critical role in many systems. However, how different cell types translate extracellular semaphorin binding into intracellular signaling remains unclear. Here we developed and performed a novel image-based genome-wide functional RNAi screen for downstream signaling… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Semaphorin regulation of cellular morphology.

  • Annual review of cell and developmental biology
  • 2007
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

FARP2 triggers signals for Sema3A-mediated axonal repulsion

  • Nature Neuroscience
  • 2005
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

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