An illustration of the use of isotopes: the biosynthesis of porphyrins.

@article{Shemin1989AnIO,
  title={An illustration of the use of isotopes: the biosynthesis of porphyrins.},
  author={David Shemin},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1989},
  volume={10 1},
  pages={30-5}
}
  • David Shemin
  • Published 1989 in
    BioEssays : news and reviews in molecular…
In this article, David Shemin, who is now in retirement, describes how in 1944 he ingested 66 g of 15N-labeled glycine in order to determine the half-life of hemoglobin and other blood proteins. The ramifications of the experiment led to the unravelling of the biosynthesis of porphyrins and the role of glycine and alpha-aminolevulinic acid in heme, vitamin B12 and chlorophyll synthesis.