An idiotypic replica of carcinoembryonic antigen inducing cellular and humoral responses directed against human colorectal tumours.

@article{Durrant1992AnIR,
  title={An idiotypic replica of carcinoembryonic antigen inducing cellular and humoral responses directed against human colorectal tumours.},
  author={Linda Gillian Durrant and Garfield Denton and Elizabeth M. Jacobs and Maureen P Mee and Robert G. Moss and Eric B. Austin and Robert W. Baldwin and Jack Donald Hardcastle and Richard A Robins},
  journal={International journal of cancer},
  year={1992},
  volume={50 5},
  pages={
          811-6
        }
}
A monoclonal anti-idiotypic antibody (anti-Id MAb) 708 (IgG2b), which inhibited the binding of NCRC23 (IgG1) MAb to CEA and prevented radiolabelled CEA from binding to MAb NCRC23, was produced. No recognition of 3 other anti-CEA antibodies, 3 other IgG1 or 2 IgM MAbs was observed with this anti-idiotypic antibody. When an immunoblotting technique was used, 708 anti-Id MAb failed to bind to isolated heavy or light chains of MAb NCRC23, whereas binding was observed with intact antibody. Mouse… CONTINUE READING
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