An fMRI-based neurologic signature of physical pain.

Abstract

BACKGROUND Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds promise for identifying objective measures of pain, but brain measures that are sensitive and specific to physical pain have not yet been identified. METHODS In four studies… (More)
DOI: 10.1056/NEJMoa1204471

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