An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.

@article{Deluca2007AnEO,
  title={An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.},
  author={Gabriele C Deluca and Sreeram V Ramagopalan and Blanca Marcela Herrera and David A Dyment and Matthew Lincoln and Alexandre Montpetit and Maura Pugliatti and Martin C. N. M. Barnardo and Neil J. Risch and Adele Dessa Sadovnick and Michael J. Chao and Stefano Sotgiu and Thomas J. Hudson and George Cornell Ebers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 52},
  pages={20896-901}
}
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for variability in disease outcome. A cohort of sporadic MS cases (n = 163), taken from opposite extremes of the distribution of long-term outcome, was used to determine the role of the HLA-DRB1 locus on MS disease severity. Genotyping sets of benign and malignant MS patients showed that HLA-DRB1*01 was significantly underrepresented in malignant compared with benign cases. This allele appears to… CONTINUE READING

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