An extract from medical leech improve the function of endothelial cells in vitro and attenuates atherosclerosis in ApoE null mice by reducing macrophages in the lesions.

@article{Wang2014AnEF,
  title={An extract from medical leech improve the function of endothelial cells in vitro and attenuates atherosclerosis in ApoE null mice by reducing macrophages in the lesions.},
  author={Yao Wang and Xin Zhao and Yun-Shan Wang and Shu-Liang Song and Hao Liang and Aiguo Ji},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={455 1-2},
  pages={119-25}
}
AIM Medicinal leech has been widely used as a traditional Chinese medicine in cardiovascular diseases. However, its pharmaceutical effect is not fully revealed. The goal of this study was to determine whether a leech extract has the effect of anti-atherosclerosis in ApoE −/− mice and the mechanism of this effect. METHODS AND RESULTS In vivo experiments: ApoE −/− mice fed on high-cholesterol diet were separated into 5 groups. Control group was administrated with normal water; leech extract of… CONTINUE READING
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