An extracorporeal blood-cleansing device for sepsis therapy

  title={An extracorporeal blood-cleansing device for sepsis therapy},
  author={Joo H. Kang and Michael Super and Chong Wing Yung and Ryan M. Cooper and Karel Domansk{\'y} and Amanda R. Graveline and Tadanori Mammoto and Julia B Berthet and Heather Tobin and Mark J. Cartwright and Alexander L. Watters and Martin Rottman and Anna Waterhouse and Akiko Mammoto and Nazita Gamini and Melissa J Rodas and Anxhela Kole and Amanda Jiang and Thomas M. Valentin and Alexander Diaz and Kazue Takahashi and Donald E. Ingber},
  journal={Nature Medicine},
Here we describe a blood-cleansing device for sepsis therapy inspired by the spleen, which can continuously remove pathogens and toxins from blood without first identifying the infectious agent. Blood flowing from an infected individual is mixed with magnetic nanobeads coated with an engineered human opsonin—mannose-binding lectin (MBL)—that captures a broad range of pathogens and toxins without activating complement factors or coagulation. Magnets pull the opsonin-bound pathogens and toxins… 
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