An extracellular matrix microarray for probing cellular differentiation

@article{Flaim2005AnEM,
  title={An extracellular matrix microarray for probing cellular differentiation},
  author={Christopher Jason Flaim and Shu Chien and Sangeeta N. Bhatia},
  journal={Nature Methods},
  year={2005},
  volume={2},
  pages={119-125}
}
We present an extracellular matrix (ECM) microarray platform for the culture of patterned cells atop combinatorial matrix mixtures. This platform enables the study of differentiation in response to a multitude of microenvironments in parallel. The fabrication process required only access to a standard robotic DNA spotter, off-the-shelf materials and 1,000 times less protein than conventional means of investigating cell-ECM interactions. To demonstrate its utility, we applied this platform to… 
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