An extra-pancreatic direct effect of streptozotocin on the hypothalamo-hypophyseal-testicular axis in the rat.


Streptozotocin induced diabetes mellitus in 4 out of 6 male rats. On the other hand, all 6 drug-injected animals had decreased serum testosterone values. The Leydig cells from 6 control rats and all streptozotocin-injected animals were characterized by moderate numbers of mitochondria, few lipid droplets, and an abundance of smooth surfaced endoplasmic… (More)


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