An extra dose of rituximab improves clinical response in rheumatoid arthritis patients with initial incomplete B cell depletion: a randomised controlled trial.

@article{Vital2015AnED,
  title={An extra dose of rituximab improves clinical response in rheumatoid arthritis patients with initial incomplete B cell depletion: a randomised controlled trial.},
  author={E M Vital and Shouvik Dass and M H Buch and Andrew C Rawstron and P T J Emery},
  journal={Annals of the rheumatic diseases},
  year={2015},
  volume={74 6},
  pages={1195-201}
}
OBJECTIVES Since clinical non-response to 2×1000 mg rituximab has previously been found to be associated with incomplete B cell depletion, we determined, in a randomised controlled proof of concept study, whether patients with initial incomplete B cell depletion would benefit from an additional infusion of rituximab at week 4. METHODS Patients with active… CONTINUE READING