An external loop region of domain III of dengue virus type 2 envelope protein is involved in serotype-specific binding to mosquito but not mammalian cells.

@article{Hung2004AnEL,
  title={An external loop region of domain III of dengue virus type 2 envelope protein is involved in serotype-specific binding to mosquito but not mammalian cells.},
  author={Jan-Jong Hung and Meng-Ti Hsieh and Ming-Jer Young and Chuan-Liang Kao and Chwan-Chuen King and Wen Chang},
  journal={Journal of virology},
  year={2004},
  volume={78 1},
  pages={378-88}
}
Dengue virus (DV) is a flavivirus and infects mammalian cells through mosquito vectors. This study investigates the roles of domain III of DV type 2 envelope protein (EIII) in DV binding to the host cell. Recombinant EIII interferes with DV infection to BHK21 and C6/36 cells by blocking dengue virion adsorption to these cells. Inhibition of EIII on BHK21 cells was broad with no serotype specificity; however, inhibition of EIII on C6/36 cells was relatively serotype specific. Soluble heparin… CONTINUE READING

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