An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for systemic lupus erythematosus

  title={An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for systemic lupus erythematosus},
  author={Henk A. Martens and Ilja Maria Nolte and Gerrit van der Steege and Martin Schipper and Cees G. M. Kallenberg and Gerard J. te Meerman and Marc Bijl},
  journal={Scandinavian Journal of Rheumatology},
  pages={256 - 262}
Objectives: The association of systemic lupus erythematosus (SLE) with the human leucocyte antigen (HLA) region is well known. In this study, we analysed the involvement of the HLA region in susceptibility for SLE in a stable founder, Caucasian population of SLE patients. Methods: We performed an extensive screen of the entire HLA region on 103 SLE patients and family‐based controls. Both single locus association analysis and haplotype sharing analysis were performed. The Additional Disease… 
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