An extended Myc network contributes to glucose homeostasis in cancer and diabetes.

@article{Peterson2011AnEM,
  title={An extended Myc network contributes to glucose homeostasis in cancer and diabetes.},
  author={Christopher W. Peterson and Donald E. Ayer},
  journal={Frontiers in bioscience},
  year={2011},
  volume={16},
  pages={2206-23}
}
The Myc network of transcription factors plays pleiotropic roles in normal and pathological cell function. The canonical Myc network controls how the essential nutrients glucose and glutamine are utilized inside cells. The Myc network carries out this function by upregulating glucose and glutamine transporters and key enzymes in the glycolytic or glutaminolytic pathways. The Myc network also coordinates cellular utilization of glucose and glutamine in biosynthetic pathways by directly… CONTINUE READING