An expression system to screen for inhibitors of parasite glucose transporters.

@article{Feistel2008AnES,
  title={An expression system to screen for inhibitors of parasite glucose transporters.},
  author={Torben Feistel and Cheryl A Hodson and David H Peyton and Scott M Landfear},
  journal={Molecular and biochemical parasitology},
  year={2008},
  volume={162 1},
  pages={71-6}
}
Chemotherapy of parasitic protists is limited by general toxicity, high expense and emergence of resistance to currently available drugs. Thus methods to identify new leads for further drug development are increasingly important. Previously, glucose transporters have been validated as new drug targets for protozoan parasites including Plasmodium falciparum, Leishmania mexicana and Trypanosoma brucei. A recently derived glucose transporter null mutant (Deltalmgt) of L. mexicana was used to… CONTINUE READING