An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.

@article{Miller2005AnES,
  title={An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.},
  author={Lance D. Miller and Johanna Smeds and Joshy George and Vinsensius B. Vega and Liza A Vergara and Alexander Ploner and Yudi Pawitan and Per Hall and Sigrid Klaar and Edison T. Liu and Jonas Bergh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 38},
  pages={13550-5}
}
Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by using sequence analysis and immunohistochemistry, are incomplete assessors of p53 functional effects. We posited that the transcriptional fingerprint is a more definitive downstream indicator of p53 function. Herein, we analyzed transcript profiles of 251 p53-sequenced primary breast tumors and identified a clinically embedded 32-gene… CONTINUE READING
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