An expression signature classifies chemotherapy-resistant pediatric osteosarcoma.

  title={An expression signature classifies chemotherapy-resistant pediatric osteosarcoma.},
  author={Michelle B Mintz and Rebecca Sowers and Kevin M Brown and Sara Hilmer and BethAnne Mazza and Andrew G. Huvos and Paul A. Meyers and Bonnie Lafleur and Wendy S. McDonough and Michael M. Henry and Keri E. Ramsey and Cristina R Antonescu and Wen Chen and John H. Healey and Aaron Daluski and Michael E. Berens and Tobey J Macdonald and Richard Greg Gorlick and Dietrich A. Stephan},
  journal={Cancer research},
  volume={65 5},
Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor survival outcome and to identify potential novel therapeutic targets. Expression profiling of 30 osteosarcoma diagnostic biopsy samples, 15 with inferior necrosis following induction… CONTINUE READING


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