An exposed cysteine residue of human angiostatic mini tryptophanyl-tRNA synthetase.

Abstract

Human tryptophanyl-tRNA synthetase (TrpRS) catalyzes the aminoacylation of tRNA(Trp). Human TrpRS exists in two forms: a major form that is the full-length protein and a truncated form (mini TrpRS) in which most of the N-terminal extension is absent. Human mini, but not full-length, TrpRS has angiostatic activity. Because the full-length protein, which… (More)
DOI: 10.1021/bi1000239

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