An exploratory study into the role of dynamic contrast-enhanced magnetic resonance imaging or perfusion computed tomography for detection of intratumoral hypoxia in head-and-neck cancer.

@article{Newbold2009AnES,
  title={An exploratory study into the role of dynamic contrast-enhanced magnetic resonance imaging or perfusion computed tomography for detection of intratumoral hypoxia in head-and-neck cancer.},
  author={Katie L. Newbold and Isabel Castellano and Elizabeth Charles-Edwards and Dorothy Mears and Aslam S. Sohaib and Martin J. Leach and Peter Rhŷs-Evans and Peter Clarke and Cyril Fisher and Kevin Harrington and Christopher M. Nutting},
  journal={International journal of radiation oncology, biology, physics},
  year={2009},
  volume={74 1},
  pages={29-37}
}
PURPOSE Hypoxia in patients with head-and-neck cancer (HNC) is well established and known to cause radiation resistance and treatment failure in the management of HNC. This study examines the role of parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perfusion computed tomography (CT) as surrogate markers of intratumoral hypoxia, defined by using the exogenous marker of hypoxia pimonidazole and the endogenous marker carbonic anhydrase 9 (CA9). METHODS… CONTINUE READING
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