An exploratory instrumental variable analysis of the outcomes of localized breast cancer treatments in a medicare population.

@article{Hadley2003AnEI,
  title={An exploratory instrumental variable analysis of the outcomes of localized breast cancer treatments in a medicare population.},
  author={Jack Hadley and Daniel E. Polsky and Jeanne S. Mandelblatt and Jean M. Mitchell and Jane C. Weeks and Qin Wang and Yi-Ting Hwang},
  journal={Health economics},
  year={2003},
  volume={12 3},
  pages={
          171-86
        }
}
This study is motivated by the potential problem of using observational data to draw inferences about treatment outcomes when experimental data are not available. We compare two statistical approaches, ordinary least-squares (OLS) and instrumental variables (IV) regression analysis, to estimate the outcomes (three-year post-treatment survival) of three treatments for early stage breast cancer in elderly women: mastectomy (MST), breast conserving surgery with radiation therapy (BCSRT), and… 
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Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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61 Citations

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This paper identifies the marginal patients and applies the method of local instrumental variables to estimate the Average Treatment Effect and the Effect on the Treated on 5-year direct costs of breast conserving surgery and radiation therapy compared to mastectomy in breast cancer patients.
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This paper identifies the marginal patients and applies the method of local IVs to estimate the average treatment effect and the effect on the treated on 5-year direct costs of breast-conserving surgery and radiation therapy compared with mastectomy in breast cancer patients.
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Overall survival has increased among patients with MM receiving HSCT, and this finding was consistent across statistical methods, indicating robustness of the findings.
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Instrumental variable analysis revealed that, for patients whose treatment choices were influenced by rates of resection in their geographic region, pancreatectomy was associated with a statistically significant increase in overall survival.
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