Ginsenoside Rb1 reduces neurodegeneration in the peri-infarct area of a thromboembolic stroke model in non-human primates.
Nicky Gordon is the Dr Hadwen Trust's Science Officer (Communications). Nicky has a background in the biological sciences, having studied Zoology and Psychology at Bristol University, before going on to take an MSc in Primate Conservation. Nicky has extensive experience in non-animal replacement techniques, having worked in the field for a number of years. Dr Gill Langley's PhD in neurochemistry was from Cambridge University and she has experience of cell culture research. Since 1979 she has led science programmes at the Dr Hadwen Trust for Humane Research. The Dr Hadwen Trust is the UK's leading medical research charity funding exclusively non-animal research techniques to replace animal experiments, benefiting people and animals. Michelle Hudson, a Scientific Officer at FRAME, has a masters degree in Zoology from the University of Sheffield. Her main research interests are the application of methods to reduce the number of animals used in experiments, the refinement of animal procedures and the replacement of non-human primates in biomedical science. Michelle is currently undertaking a PhD at the Institute for Science and Society, University of Nottingham, investigating the use of non-human primates in biomedical research. Christine Brock holds a first class honours degree in Herbal Medicine, was awarded the 2007 Phytoproducts prize for Pharmacology, and is currently undertaking a Health and Wellbeing PhD at the University of Westminster. She previously had a career as a biomedical scientist, specialising in histology, and is a Member of the Institute of Biomedical Sciences. She has also been a senior NHS manager, overseeing human research ethics committees. An important feature missing from most previous publications is a detailed analysis of the extent to which primate experiments have already been replaced by advanced non-animal alternatives such as cell and molecular methods, computer simulations and ethical studies with human volunteers (see panel). This report aims to fill that gap. It is important because knowledge of these successes will foster a more widespread sense that primate research can be replaced with valid techniques that do not use laboratory animals. We selected five areas of medical research into important human conditions – malaria, cognition, stroke, AIDS and hepatitis C – which have used significant numbers of primates over many years and yet have had very limited success in translating to human benefit. They illustrate where notable progress has been made in replacing primate experiments with non-animal techniques, and where greater progress is achievable. Around the world many …