An experimental study of topiramate with monotherapy in febrile seizure in rats

@inproceedings{Zhi2003AnES,
  title={An experimental study of topiramate with monotherapy in febrile seizure in rats},
  author={Huang Zhi},
  year={2003}
}
Objective:To observe the prophylactic effect and side effects of topiramate(TPM)with monotherapy in febrile seizure in rats.Methods:Sixty Wistar rats were equally randomized into two groups and were administered4mg or8mg TPM per kg of body weight per day by a gastric tube for20days.The susceptiveness to hot bath after treated with TPM and side effects were observed.Results:The la-tent period of seizure of rats exposed to hot bath which treated with TPM was significantly delayed from(247.8±84.9… CONTINUE READING

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