An experimental porcine model of partial ischaemia of the distal colon.


OBJECTIVE Ischaemia of the colon is a major challenge in aortoiliac surgery. The aim was to establish an animal model of partial distal colonic ischaemia to study interventional strategies. DESIGN Randomised experiment. SETTING University Hospital. Department of Experimental Research. MATERIAL 19 pigs. INTERVENTIONS 11 Pigs were subjected to ischaemia consisting of total occlusion of the inferior mesenteric artery and partial occlusion of the superior mesenteric artery. Eight animals were sham controls. Dextran was given. MAIN OUTCOME MEASURES Haemodynamic measurements, intramucosal pH-measurements (pHi) and histological grading. RESULTS Both ischaemic animals and controls remained haemodynamically stable. It was possible to maintain stable ischaemia in the distal colon in the pHi-range of 6.9-7.1. There was histological mucosal damage of the distal colon in ischaemic animals but not in controls. CONCLUSIONS The model could be of value when studying interventional strategies to reduce or reverse ischaemia.

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@article{Bjrck1997AnEP, title={An experimental porcine model of partial ischaemia of the distal colon.}, author={Martin Bj{\"{o}rck and David Bergqvist and I B Rasmussen and Estee Piehl and Ulf H. Haglund}, journal={The European journal of surgery = Acta chirurgica}, year={1997}, volume={163 11}, pages={843-50} }