An experimental platform for systemic drug delivery to the retina.

  title={An experimental platform for systemic drug delivery to the retina.},
  author={Matthew S Campbell and Anh Thi Hong Nguyen and A S Kiang and Lawrence C. S. Tam and Oliviero L Gobbo and Christian Kerskens and Sorcha S N{\'i} Dhubhghaill and Marian M. Humphries and G. Jane Farrar and Paul F. Mc Kenna and Peter Humphries},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 42},
Degenerative retinopathies, including age-related macular degeneration, diabetic retinopathy, and hereditary retinal disorders--major causes of world blindness--are potentially treatable by using low-molecular weight neuroprotective, antiapoptotic, or antineovascular drugs. These agents are, however, not in current systemic use owing to, among other factors, their inability to passively diffuse across the microvasculature of the retina because of the presence of the inner blood-retina barrier… CONTINUE READING


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Publications referenced by this paper.
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Effect of gene therapy on visual function in Leber’s congenital amaurosis

JW Bainbridge
N Engl J Med • 2008

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View 1 Excerpt

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AM Maguire
N Engl J Med • 2008

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