An experimental model simulating local recurrence and pelvic lymph node metastasis following orthotopic induction of prostate cancer.

Abstract

In order to develop an animal model that more closely simulates the organ environment and metastatic routes of human prostatic cancer, R3327-MatLyLu tumors were induced by orthotopic implantation in the ventral prostatic lobe of Copenhagen rats. This procedure reproducibly resulted in metastatic spread of the intraprostatic tumor to the pelvic and retroperitoneal lymph nodes, and invariably to the lungs. Further, a tumor recurrence model was established using an approach that combined orthotopic tumor implantation and subsequent surgical resection of the primary tumor. When prostatectomy was carried out 4 days or more after induction, tumors recurred locally in all animals. The surgical procedures described may provide an animal model to test the in vivo response to experimental adjuvant treatment protocols for advanced prostate cancer. Immunological studies are now in progress using cytokine gene-modified prostatic tumor cells as cellular antitumor vaccines in orthotopically established R3327-MatLyLu tumors.

Statistics

050100'99'01'03'05'07'09'11'13'15'17
Citations per Year

195 Citations

Semantic Scholar estimates that this publication has 195 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Vieweg1994AnEM, title={An experimental model simulating local recurrence and pelvic lymph node metastasis following orthotopic induction of prostate cancer.}, author={Johannes W G Vieweg and Warren D. W. Heston and Eli Gilboa and William R. Fair}, journal={The Prostate}, year={1994}, volume={24 6}, pages={291-8} }