An experimental model for the study of the antibacterial activity of the sulfonamides.

@article{Sanfilippo1968AnEM,
  title={An experimental model for the study of the antibacterial activity of the sulfonamides.},
  author={Aurora Sanfilippo and E. Morvillo},
  journal={Chemotherapia},
  year={1968},
  volume={13 1},
  pages={
          54-60
        }
}
View on PubMed
doi.org
20 Citations
Background Citations
3
Methods Citations
2

20 Citations

Citation Type

Citation Type

Pharmacodynamic In Vitro Models to Determine the Effect of Antibiotics
TLDR
Based on the experimental conditions and results a mathematical model describing the relationships between the effective concentration of the drug, the pharmacological effect, and time can be obtained and this information can be used to support dose selection in a more rational manner.
Principles of Applied Pharmacokinetic–Pharmacodynamic Modeling
TLDR
Capturing the time course of microbial dynamics in a kill-curve system provides an opportunity for complex PKPD modeling that has been used to evaluate challenging topics such as antimicrobial resistance.
Pharmacometrics in Bacterial Infections
TLDR
The approaches in designing treatment strategies using minimum inhibitory concentrations and in vitro time course of bacterial killing are explained to provide a thorough overview of the current state-of-the-art exploration of antimicrobial pharmacokinetic–pharmacodynamic (PKPD) modeling and simulation.
Bactericidal Activity of Ofloxacin versus Roxithromycin in the Treatment of Streptococcus pneumoniae
TLDR
The bactericidal activities of ofloxacin and roxithromycin were evaluated against 15 strains of S. pneumoniae, which were isolated recently from clinical specimens and under conditions simulating serum pharmacokinetic parameters, roxmithromycin was rapidly bactericidal.
Effects of two simulated oxytetracycline dosing regimens on horizontal transfer of antimicrobial resistance plasmids in an in vitro pharmacodynamic model.
TLDR
Transfer of antimicrobial resistance plasmids may be suppressed in vitro by oxytetracycline exposure at concentrations greater than the minimum inhibitory concentration of the recipient bacteria.
In vitro pharmacodynamic models to determine the effect of antibacterial drugs.
TLDR
An overview of in vitro PD models and their experimental implementation is provided, including the simulations of various in vivo routes of administration of single drugs or drug combinations against bacteria.
The impact of oxytetracycline dosing on bacterial populations and transfer of resistance elements in vitro and in vivo
TLDR
The results presented here show that the bacterial response to oxytetracycline can be optimized in a concentration dependent manner and that antimicrobial resistance development through plasmid transfer can be suppressed in vitro when oxytETRACYcline concentrations exceed the MIC of the recipient bacteria.
In Vitro Dynamic Models as Tools to Predict Antibiotic Pharmacodynamics
A Novel In Vitro Pharmacokinetic/Pharmacodynamic Model Based on Two‐Compartment Open Model Used to Simulate Serum Drug Concentration‐Time Profiles
An in vitro pharmacokinetic/pharmacodynamic perfusion model that simulates a two‐compartment open model of serum drug concentration‐time profiles following intravenous bolus injection and infusion…
Combined action of decreasing concentrations of azlocillin and sisomicin on pseudomonas aeruginosa as assessed in a dynamic in vitro model
TLDR
Neither pre-treatment with azlocillin nor with sisomicin impaired the antibacterial activity of the combination partner, which seems to be of clinical importance since the agents may be administered at different times during combined therapy.
...
...